BT6201 BIOCHEMISTRY Syllabus | Anna University Regulation 2013 BE/B Tech First Year Second Semester Syllabus. Below is the Anna University 2013 Regulation Syllabus for 2nd Semester for Biotechnology, Textbooks, Reference books, Exam portions, Question Bank, Previous year question papers, Model question papers, Class notes, Important 2 marks, 8 marks, 16 marks topics. It is applicable for all students admitted in the Academic year 2013-2014 onwards for all its Affiliated institutions in Tamil nadu.
To develop understanding and provide scientific basics of the life processes at the
molecular level and explain the structure, function and inter-relationships of bio-molecules
and their deviation from normal and their consequences for interpreting and solving clinical
problems.
7
UNIT I BIOCHEMICAL ORGANIZATION AND BIOENERGETICS 10
Scope of clinical biochemistry, component of the cell, structure and biochemical functions,
membrane structure and functions, transport through biological cell membrane, the concept of free
energy, determination of change in free energy from equilibrium constant and reduction potential,
bioenergetics and biological oxidation – general concept of oxidation and reduction, electron
transport chain, oxidative phosphorylation, uncouplers and theories of biological oxidation and
oxidative phosphorylation
UNIT II BIOMOLECULES 12
Carbohydrates – classification, properties.starch, glycogen, dextrin, inulin, cellulose, metabolism
of carbohydrates – gluconeogenesis, glycogenolysis, glycolysis. citric acid cycle and its biological
significance, role of sugar in nucleotide biosynthesis and pentose phosphate pathway. Lipids –
Classification, properties. sterols, essential fatty acids, eicosanoids, phospholipids, sphingolipids,
metabolism of lipids, oxidation of fatty acids, α,β - oxidation and biosynthesis of ketone bodies,
cholesterol, porphyrin biosynthesis, metabolism of bile pigments. Proteins and amino acids –
Classification, properties, biosynthesis of amino acids and proteins, essential amino acids,
metabolism of amino acids and proteins, Nitrogen balance. Nucleic acids –genetic code, nucleic
acids, and structure of DNA and RNA, purine biosynthesis and pyrimidine biosynthesis.
UNIT III BIOENERGETICS 5
High energy compounds , electronegative potential of compounds , respiratory chain , ATP cycle ,
Calculation of ATP during oxidation of glucose and fatty acids.
UNIT IV MACROMOLECULES, VITAMINS, HORMONES, ENZYMES 10
Physical and chemical properties, structure of haemoglobin, immunoglobulins and nucleoprotein,
classification and their properties, occurrence, functions, requirements, deficiency manifestations
and role of vitamins as coenzyme, chemical nature and properties, hormones, Nomenclature,
enzyme kinetics, classification and their properties, mechanism of action, enzyme induction and
inhibition, coenzyme significance and enzymes of clinical importance
UNIT V BIOCHEMISTRY OF CLINICAL DISEASES 8
Diabetes mellitus, atherosclerosis, fatty liver, and obesity, hormonal disorders, aging, inborn errors
of metabolism organ function tests
TOTAL: 45 PERIODS
TEXTBOOKS
1. Lehninger A.L., Nelson D.L. and Cox M.M. Principles of Biochemistry. CBS publishers and
distributers
2. Murray R.K., Granner D.K., Mayes P.A. and Rodwell V.W. Harpers Biochemistry. Appleton
and Lange ,Stanford ,Conneticut.
3. Thomas M. Devlin.Textbook of Biochemistry with clinical correlations. Wiley Liss Publishers
REFERENCES
1. Burtis & Ashwood W.B. Tietz Textbook of Clinical chemistry. Saunders Company
2. Lubert Stryer W.H. Biochemistry. Freeman and company, New york.
3. Donald Voet & Judith G. Voet. Biochemistry. John Wiley and Sons ,Inc.
4. Rama Rao Textbook of Biochemistry.
5. Deb. Textbook of Biochemistry.
BT6201 BIOCHEMISTRY L T P C 3 0 0 3
OBJECTIVES To develop understanding and provide scientific basics of the life processes at the
molecular level and explain the structure, function and inter-relationships of bio-molecules
and their deviation from normal and their consequences for interpreting and solving clinical
problems.
7
UNIT I BIOCHEMICAL ORGANIZATION AND BIOENERGETICS 10
Scope of clinical biochemistry, component of the cell, structure and biochemical functions,
membrane structure and functions, transport through biological cell membrane, the concept of free
energy, determination of change in free energy from equilibrium constant and reduction potential,
bioenergetics and biological oxidation – general concept of oxidation and reduction, electron
transport chain, oxidative phosphorylation, uncouplers and theories of biological oxidation and
oxidative phosphorylation
UNIT II BIOMOLECULES 12
Carbohydrates – classification, properties.starch, glycogen, dextrin, inulin, cellulose, metabolism
of carbohydrates – gluconeogenesis, glycogenolysis, glycolysis. citric acid cycle and its biological
significance, role of sugar in nucleotide biosynthesis and pentose phosphate pathway. Lipids –
Classification, properties. sterols, essential fatty acids, eicosanoids, phospholipids, sphingolipids,
metabolism of lipids, oxidation of fatty acids, α,β - oxidation and biosynthesis of ketone bodies,
cholesterol, porphyrin biosynthesis, metabolism of bile pigments. Proteins and amino acids –
Classification, properties, biosynthesis of amino acids and proteins, essential amino acids,
metabolism of amino acids and proteins, Nitrogen balance. Nucleic acids –genetic code, nucleic
acids, and structure of DNA and RNA, purine biosynthesis and pyrimidine biosynthesis.
UNIT III BIOENERGETICS 5
High energy compounds , electronegative potential of compounds , respiratory chain , ATP cycle ,
Calculation of ATP during oxidation of glucose and fatty acids.
UNIT IV MACROMOLECULES, VITAMINS, HORMONES, ENZYMES 10
Physical and chemical properties, structure of haemoglobin, immunoglobulins and nucleoprotein,
classification and their properties, occurrence, functions, requirements, deficiency manifestations
and role of vitamins as coenzyme, chemical nature and properties, hormones, Nomenclature,
enzyme kinetics, classification and their properties, mechanism of action, enzyme induction and
inhibition, coenzyme significance and enzymes of clinical importance
UNIT V BIOCHEMISTRY OF CLINICAL DISEASES 8
Diabetes mellitus, atherosclerosis, fatty liver, and obesity, hormonal disorders, aging, inborn errors
of metabolism organ function tests
TOTAL: 45 PERIODS
TEXTBOOKS
1. Lehninger A.L., Nelson D.L. and Cox M.M. Principles of Biochemistry. CBS publishers and
distributers
2. Murray R.K., Granner D.K., Mayes P.A. and Rodwell V.W. Harpers Biochemistry. Appleton
and Lange ,Stanford ,Conneticut.
3. Thomas M. Devlin.Textbook of Biochemistry with clinical correlations. Wiley Liss Publishers
REFERENCES
1. Burtis & Ashwood W.B. Tietz Textbook of Clinical chemistry. Saunders Company
2. Lubert Stryer W.H. Biochemistry. Freeman and company, New york.
3. Donald Voet & Judith G. Voet. Biochemistry. John Wiley and Sons ,Inc.
4. Rama Rao Textbook of Biochemistry.
5. Deb. Textbook of Biochemistry.
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