BT2027 CANCER BIOLOGY SYLLABUS | ANNA UNIVERSITY BTECH BIOTECHNOLOGY 6TH SEMESTER SYLLABUS REGULATION 2008 2011 2012-2013 BELOW IS THE ANNA UNIVERSITY SIXTH SEMESTER B.TECH BIOTECHNOLOGY DEPARTMENT SYLLABUS, TEXTBOOKS, REFERENCE BOOKS,EXAM PORTIONS,QUESTION BANK,PREVIOUS YEAR QUESTION PAPERS,MODEL QUESTION PAPERS, CLASS NOTES, IMPORTANT 2 MARKS, 8 MARKS, 16 MARKS TOPICS. IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011 2012-2013 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI, TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
BT2027 CANCER BIOLOGY L T P C
3 0 0 3
AIM
To develop skills of the students in the area of Cancer Biology.
OBJECTIVES
At the end of the course, the student would have learnt about pathogenesis of
cancer, identifications of cancer through tools developed by biotechnology research
& molecules synthesized for cancer therapy. This will be very beneficial for the
student to take up projects in Cancer Biology.
UNIT I FUNDAMENTALS OF CANCER BIOLOGY 9
Regulation of cell cycle, mutations that cause changes in signal molecules, effects on
receptor, signal switches, tumour suppressor genes, modulation of cell cycle in cancer,
different forms of cancers, diet and cancer. Cancer screening and early detection,
Detection using biochemical assays, tumor markers, molecular tools for early diagnosis
of cancer.
UNIT II PRINCIPLES OF CARCINOGENESIS 12
Theory of carcinogenesis, Chemical carcinogenesis, metabolism of carcinogenesis,
principles of physical carcinogenesis, x-ray radiation-mechanisms of radiation
carcinogenesis.
UNIT III PRINCIPLES OF MOLECULAR CELL BIOLOGY OF CANCER 9
Signal targets and cancer, activation of kinases; Oncogenes, identification of oncogenes,
retroviruses and oncogenes, detection of oncogenes. Oncogenes/proto oncogene
activity. Growth factors related to transformation. Telomerases.
UNIT IV PRINCIPLES OF CANCER METASTASIS 9
Clinical significances of invasion, heterogeneity of metastatic phenotype, metastatic
cascade, basement membrane disruption, three step theory of invasion, proteinases and
tumour cell invasion.
UNIT V NEW MOLECULES FOR CANCER THERAPY 6
Different forms of therapy, chemotherapy, radiation therapy, detection of cancers,
prediction of aggressiveness of cancer, advances in cancer detection. Use of signal
targets towards therapy of cancer; Gene therapy.
TOTAL : 45 PERIODS
TEXT BOOKS
1. Maly B.W.J, “Virology A Practical Approach”, IRLl Press, Oxford, 1987.
2. Dunmock N.J And Primrose S.B., “Introduction to Modern Virology”, Blackwell
Scientific Publications, Oxford, 1988.
REFERENCE
1. “An Introduction Top Cellular And Molecular Biology of Cancer”, j Oxford Medical
Publications, 1991.
BT2027 CANCER BIOLOGY L T P C
3 0 0 3
AIM
To develop skills of the students in the area of Cancer Biology.
OBJECTIVES
At the end of the course, the student would have learnt about pathogenesis of
cancer, identifications of cancer through tools developed by biotechnology research
& molecules synthesized for cancer therapy. This will be very beneficial for the
student to take up projects in Cancer Biology.
UNIT I FUNDAMENTALS OF CANCER BIOLOGY 9
Regulation of cell cycle, mutations that cause changes in signal molecules, effects on
receptor, signal switches, tumour suppressor genes, modulation of cell cycle in cancer,
different forms of cancers, diet and cancer. Cancer screening and early detection,
Detection using biochemical assays, tumor markers, molecular tools for early diagnosis
of cancer.
UNIT II PRINCIPLES OF CARCINOGENESIS 12
Theory of carcinogenesis, Chemical carcinogenesis, metabolism of carcinogenesis,
principles of physical carcinogenesis, x-ray radiation-mechanisms of radiation
carcinogenesis.
UNIT III PRINCIPLES OF MOLECULAR CELL BIOLOGY OF CANCER 9
Signal targets and cancer, activation of kinases; Oncogenes, identification of oncogenes,
retroviruses and oncogenes, detection of oncogenes. Oncogenes/proto oncogene
activity. Growth factors related to transformation. Telomerases.
UNIT IV PRINCIPLES OF CANCER METASTASIS 9
Clinical significances of invasion, heterogeneity of metastatic phenotype, metastatic
cascade, basement membrane disruption, three step theory of invasion, proteinases and
tumour cell invasion.
UNIT V NEW MOLECULES FOR CANCER THERAPY 6
Different forms of therapy, chemotherapy, radiation therapy, detection of cancers,
prediction of aggressiveness of cancer, advances in cancer detection. Use of signal
targets towards therapy of cancer; Gene therapy.
TOTAL : 45 PERIODS
TEXT BOOKS
1. Maly B.W.J, “Virology A Practical Approach”, IRLl Press, Oxford, 1987.
2. Dunmock N.J And Primrose S.B., “Introduction to Modern Virology”, Blackwell
Scientific Publications, Oxford, 1988.
REFERENCE
1. “An Introduction Top Cellular And Molecular Biology of Cancer”, j Oxford Medical
Publications, 1991.
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