IB3217 GENETICS SYLLABUS | ANNA UNIVERSITY BTECH FOOD TECHNOLOGY 4TH SEM SYLLABUS REGULATION 2008 2011 2012-2013 BELOW IS THE ANNA UNIVERSITY FOURTH SEMESTER B TECH FOOD TECHNOLOGY DEPARTMENT SYLLABUS, TEXTBOOKS, REFERENCE BOOKS,EXAM PORTIONS,QUESTION BANK,PREVIOUS YEAR QUESTION PAPERS,MODEL QUESTION PAPERS, CLASS NOTES, IMPORTANT 2 MARKS, 8 MARKS, 16 MARKS TOPICS. IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011 2012-2013 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI, TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
IB3217 GENETICS L T P C
3 0 0 3
AIM
To introduce students to the principles of classical genetics and to emphasize the role of
genetics in modern biology.
OBJECTIVES
To provide to the students the fundamentals of classical genetics and ability to solve
problems in genetics.
To help students understand sex determination mechanisms.
To enable students appreciate genetic recombination and mapping techniques.
UNIT I CLASSICAL GENETICS 9
Mendelian genetics, symbols and terminology, monohybrid crosses, ratios, dominance ,
recessiveness, backcross, testcross, codominance, incomplete dominance, lethals
Princilples of segregation, Punett square, dihybrid cross, ratios, trihybrids,, geneic interation,
epistasis, forked line method for genetic problems.Pedigrees,probability and statistics for
geneticists.
UNIT II SEX DETERMINATION, SEX LINKAGE AND PEDIGREE ANALYSIS 9
Sex determination , patterns, sex chromosomes, dosage compensation, Lyon’s hypothesis,
dosage compensation in Drosophila, sex determination in humans, SRy, XX-XY mechanism,
Y chromosome and sex determination in mammals. Balance concept of sex determination in
Drosophila. Identification of sex chromosomes.
Sex Linkage- human sex-linked disorders hemophilia, Fragile X, Lesh-Nyhan and Hunter
syndrome.Pedigree analysis, penetrance, expressivity, dominant , recessive and sex-linked
inheritance. Sex limited, sex influenced traits, mosaics and gynandromorphs.
36
UNIT III STUCTURE OF CHROMOSOMES AND VARIATION IN CHROMOSOME
STRUCTURE AND NUMBER 9
Organization of prokaryotic and eukaryotic chromosomes. Proof that DNA is genetic
material. Cytogenenetic variation, human karyotypes, polytene chromosomes, polyploidy,
sterile polyploids, polyteny.Aneuploidy- monosomy, trisomy in humans, deletions and
duplications in chromosome number. Rearrangements of chromosome structure, inversion,
translocation, compound chromosomes, phenotypic effects of chromosome rearrangements.
UNIT IV LINKAGE, CROSSING OVER AND CHROMOSOME MAPPING IN
EUKARYOTES 9
Linkage, Crossing over, recombination, exception to Mendelian principles, frequency of
recombination, evidence of crossing over, chiasmata, chromosome mapping with two- point
and three-point testcrosses. Recombination mapping and map distance, linkage analysis in
humans , detection of linked loci by pedigree analysis and somatic cell genetics. Human
gene map.
UNIT V GENETICS OF BACTERIA AND VIRUSES 9
Structure and life cycle of bacterial viruses, mapping the bacteriophage genome, deletion
mapping. Genetic exchange in Bacteria.Transformation, process and mapping, Conjugation,
F+X F- mapping, HFR, sexduction, conjugation and gene mapping, mapping closely linked
genes, origin of plasmids. Transduction – Generalized, Specialized and gene mapping in
bacteria significance of sexuality in bacteria.
TOTAL : 45 PERIODS
TEXT BOOKS
1. Gardner, E.J., M.J. Simmons and D.P. Snustad “Principles of Genetics”.8th Edition. John
Wiley & Sons,1991.
2. Sinnott, E.W., L.C. Dunn. “Principles of Genetics”. 5th Edition, Tata McGraw-Hill, 1973.
3. Tamarin, R.H. “Principles of Genetics” 7th Edition, Tata McGraw-Hill, 2002.
4. Sambamurthy, A.V.S.S. “Genetics”. 2nd Edition, Narosa, 2005.
REFERENCES
1. Klug, William S. and M.R. Cummings. “Essentials of Genetics”. 5th Edition, Pearson
Education, 2005.
2. Russell, Peter J. “I Genetics : A Molecular Approach”. 2nd Edition, Pearson Education,
2006.
3. Brooker, R.J. “Genetics : Analysis and Principles”. 2nd Edition, McGraw-Hill, 2004.
IB3217 GENETICS L T P C
3 0 0 3
AIM
To introduce students to the principles of classical genetics and to emphasize the role of
genetics in modern biology.
OBJECTIVES
To provide to the students the fundamentals of classical genetics and ability to solve
problems in genetics.
To help students understand sex determination mechanisms.
To enable students appreciate genetic recombination and mapping techniques.
UNIT I CLASSICAL GENETICS 9
Mendelian genetics, symbols and terminology, monohybrid crosses, ratios, dominance ,
recessiveness, backcross, testcross, codominance, incomplete dominance, lethals
Princilples of segregation, Punett square, dihybrid cross, ratios, trihybrids,, geneic interation,
epistasis, forked line method for genetic problems.Pedigrees,probability and statistics for
geneticists.
UNIT II SEX DETERMINATION, SEX LINKAGE AND PEDIGREE ANALYSIS 9
Sex determination , patterns, sex chromosomes, dosage compensation, Lyon’s hypothesis,
dosage compensation in Drosophila, sex determination in humans, SRy, XX-XY mechanism,
Y chromosome and sex determination in mammals. Balance concept of sex determination in
Drosophila. Identification of sex chromosomes.
Sex Linkage- human sex-linked disorders hemophilia, Fragile X, Lesh-Nyhan and Hunter
syndrome.Pedigree analysis, penetrance, expressivity, dominant , recessive and sex-linked
inheritance. Sex limited, sex influenced traits, mosaics and gynandromorphs.
36
UNIT III STUCTURE OF CHROMOSOMES AND VARIATION IN CHROMOSOME
STRUCTURE AND NUMBER 9
Organization of prokaryotic and eukaryotic chromosomes. Proof that DNA is genetic
material. Cytogenenetic variation, human karyotypes, polytene chromosomes, polyploidy,
sterile polyploids, polyteny.Aneuploidy- monosomy, trisomy in humans, deletions and
duplications in chromosome number. Rearrangements of chromosome structure, inversion,
translocation, compound chromosomes, phenotypic effects of chromosome rearrangements.
UNIT IV LINKAGE, CROSSING OVER AND CHROMOSOME MAPPING IN
EUKARYOTES 9
Linkage, Crossing over, recombination, exception to Mendelian principles, frequency of
recombination, evidence of crossing over, chiasmata, chromosome mapping with two- point
and three-point testcrosses. Recombination mapping and map distance, linkage analysis in
humans , detection of linked loci by pedigree analysis and somatic cell genetics. Human
gene map.
UNIT V GENETICS OF BACTERIA AND VIRUSES 9
Structure and life cycle of bacterial viruses, mapping the bacteriophage genome, deletion
mapping. Genetic exchange in Bacteria.Transformation, process and mapping, Conjugation,
F+X F- mapping, HFR, sexduction, conjugation and gene mapping, mapping closely linked
genes, origin of plasmids. Transduction – Generalized, Specialized and gene mapping in
bacteria significance of sexuality in bacteria.
TOTAL : 45 PERIODS
TEXT BOOKS
1. Gardner, E.J., M.J. Simmons and D.P. Snustad “Principles of Genetics”.8th Edition. John
Wiley & Sons,1991.
2. Sinnott, E.W., L.C. Dunn. “Principles of Genetics”. 5th Edition, Tata McGraw-Hill, 1973.
3. Tamarin, R.H. “Principles of Genetics” 7th Edition, Tata McGraw-Hill, 2002.
4. Sambamurthy, A.V.S.S. “Genetics”. 2nd Edition, Narosa, 2005.
REFERENCES
1. Klug, William S. and M.R. Cummings. “Essentials of Genetics”. 5th Edition, Pearson
Education, 2005.
2. Russell, Peter J. “I Genetics : A Molecular Approach”. 2nd Edition, Pearson Education,
2006.
3. Brooker, R.J. “Genetics : Analysis and Principles”. 2nd Edition, McGraw-Hill, 2004.
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