IT2033 BIOINFORMATICS SYLLABUS | ANNA UNIVERSITY BTECH IT 7TH SEMESTER SYLLABUS REGULATION 2008 2011-2012 BELOW IS THE ANNA UNIVERSITY SEVENTH SEMESTER B.TECH. INFORMATION TECHNOLOGY DEPARTMENT SYLLABUS IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011-2012 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI,TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
IT2033 BIOINFORMATICS L T P C
3 0 0 3
UNIT I 9
Introduction to molecular biology – the genetic material – gene structure – protein
structure – chemical bonds – molecular biology tools – genomic information content
UNIT II 9
Data searches – simple alignments – gaps – scoring matrices – dynamic programming –
global and local alignments – database searches – multiple sequence alignments
Patterns for substitutions – estimating substitution numbers – evolutionary rates –
molecular clocks – evolution in organelles
UNIT III 9
Phylogenetics – history and advantages – phylogenetic trees – distance matrix methods
– maximum likelihood approaches – multiple sequence alignments – Parsimony –
ancestral sequences – strategies for faster searches – consensus trees – tree
confidence – comparison of phylogenetic methods – molecular phylogenies
UNIT IV 9
Genomics – prokaryotic genomes: prokaryotic gene structure – GC content - gene
density – eukaryotic genomes: gene structure – open reading frames – GC content –
gene expression – transposition – repeated elements – gene density
UNIT V 9
Amino acids – polypeptide composition – secondary structure – tertiary and quaternary
structure – algorithms for modeling protein folding – structure prediction – predicting
RNA secondary structures
Proteomics – protein classification – experimental techniques – inhibitors and drug
design – ligand screening – NMR structures – empirical methods and prediction
techniques – post-translational modification prediction
TOTAL: 45 PERIODS
TEXT BOOK
1. D. E. Krane and M. L. Raymer, “Fundamental concepts of Bioinformatics”, Pearson
Education, 200UNIT III
REFERENCES
1. Arthur M. Lesk, “Introduction to Bioinformatics”, Second Edition, Oxford University
Press, 2005.
2. T. K. Attwood, D. J. Parry-Smith, and S. Phukan, “Introduction to Bioinformatics”,
Pearson Education, 1999.
3. Vittal R. Srinivas, “Bioinformatics – A Modern Approach”, Prentice-Hall of India Pvt.
Ltd., 2005.
IT2033 BIOINFORMATICS L T P C
3 0 0 3
UNIT I 9
Introduction to molecular biology – the genetic material – gene structure – protein
structure – chemical bonds – molecular biology tools – genomic information content
UNIT II 9
Data searches – simple alignments – gaps – scoring matrices – dynamic programming –
global and local alignments – database searches – multiple sequence alignments
Patterns for substitutions – estimating substitution numbers – evolutionary rates –
molecular clocks – evolution in organelles
UNIT III 9
Phylogenetics – history and advantages – phylogenetic trees – distance matrix methods
– maximum likelihood approaches – multiple sequence alignments – Parsimony –
ancestral sequences – strategies for faster searches – consensus trees – tree
confidence – comparison of phylogenetic methods – molecular phylogenies
UNIT IV 9
Genomics – prokaryotic genomes: prokaryotic gene structure – GC content - gene
density – eukaryotic genomes: gene structure – open reading frames – GC content –
gene expression – transposition – repeated elements – gene density
UNIT V 9
Amino acids – polypeptide composition – secondary structure – tertiary and quaternary
structure – algorithms for modeling protein folding – structure prediction – predicting
RNA secondary structures
Proteomics – protein classification – experimental techniques – inhibitors and drug
design – ligand screening – NMR structures – empirical methods and prediction
techniques – post-translational modification prediction
TOTAL: 45 PERIODS
TEXT BOOK
1. D. E. Krane and M. L. Raymer, “Fundamental concepts of Bioinformatics”, Pearson
Education, 200UNIT III
REFERENCES
1. Arthur M. Lesk, “Introduction to Bioinformatics”, Second Edition, Oxford University
Press, 2005.
2. T. K. Attwood, D. J. Parry-Smith, and S. Phukan, “Introduction to Bioinformatics”,
Pearson Education, 1999.
3. Vittal R. Srinivas, “Bioinformatics – A Modern Approach”, Prentice-Hall of India Pvt.
Ltd., 2005.
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